Heart & Vascular Diseases Genetics
Vascular occlusion or Thrombosis is when a vein is blocked by a blood clot that forms inside a vein. Venous thrombosis is the name given to the formation of blood clots in the veins. If thrombosis in a vein is detached from the place where it first occurred and travels inside a vein, it is called an embolism.
Causes Of Thrombosis
Risk Factors That Predispose To Thrombosis And That Occur Later
These factors include conditions such as pregnancy, obesity, old age, smoking, blood diseases such as polycythemia, essential thrombocythemia, antiphospholipid syndrome, diseases that adversely affect all systems such as heart failure, cancer and nephrotic syndrome, the use of drugs such as birth control pills, erythropoietin, tamoxifen, thalidomide, includes surgeries and trauma, particularly affecting the large vessels. Inactivity during long journeys (especially air travels that take six hours or more) and prolonged bed rest due to diseases are also factors that increase the development of blood clots.
Inherited (Genetic) Risk Factors In Thrombosis
A tendency for thrombosis is called thrombophilia. Hereditary thrombophilia refers to genetic problems that cause blood clots to form more easily than normal individuals. Hereditary risk factors such as Antithrombin, Protein C or Protein S deficiency predispose to clot formation in patients younger than 50 years old.
If a patient with thrombosis has no known disease or recent surgery, the presence of inherited risk factors should be considered.
Problems Caused By Genes And Mutations Related To Hereditary Thrombosis:
At our center, Thrombophilia Panels for your Cardiovascular Genetics and many different genetic tests and cardiology panels for related genes are held.